Version 5.4
Homo sapiens Gene: IARS2
Summary
InnateDB Gene IDBG-106737.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IARS2
Gene Name isoleucyl-tRNA synthetase 2, mitochondrial
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000067704
Encoded Proteins
IDBP-106739
isoleucyl-tRNA synthetase 2, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:220094102-220148041
Strand Forward strand
Band q41
Transcripts
ENST00000366922 ENSP00000355889
ENST00000490891
ENST00000488777
ENST00000467924
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0003824 catalytic activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004822 isoleucine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006428 isoleucyl-tRNA aminoacylation
GO:0006450 regulation of translational fidelity
GO:0010467 gene expression
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026618
View Gene Order
ENSBTAG00000012582
Not yet available
Pathways
NETPATH
REACTOME
REACT_15302
Mitochondrial tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
hsa00970
Aminoacyl-tRNA biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q9NSE4
TrEMBL F6SBX2
UniProt Splice Variant
Entrez Gene 55699
UniGene Hs.262823 Hs.614391
RefSeq NM_018060
HUGO HGNC:29685
OMIM 612801
CCDS CCDS1523
HPRD
IMGT
EMBL AC103590 AK001188 AK022665 AY267462 BC010218 BC040376 BC047880 BC137438 CH471100 D28500
GenPept AAH10218 AAH40376 AAH47880 AAI37439 AAP94033 BAA91544 BAA95147 BAB14164 EAW93305
RNA Seq Atlas 55699

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca