Version 5.4
Homo sapiens Gene: CAPN2
Summary
InnateDB Gene IDBG-106873.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPN2
Gene Name calpain 2, (m/II) large subunit
Synonyms CANP2; CANPL2; CANPml; mCANP
Species Homo sapiens
Ensembl Gene ENSG00000162909
Encoded Proteins
IDBP-106877
calpain 2, (m/II) large subunit
IDBP-390045
calpain 2, (m/II) large subunit
IDBP-390046
calpain 2, (m/II) large subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5\' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:223701593-223776018
Strand Forward strand
Band q41
Transcripts
ENST00000295006 ENSP00000295006
ENST00000434648 ENSP00000399949
ENST00000433674 ENSP00000413158
ENST00000483579
ENST00000480581
ENST00000474026
ENST00000487223
ENST00000492565
ENST00000472601
ENST00000498027
ENST00000492664
ENST00000463997
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 50 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001666 response to hypoxia
GO:0001824 blastocyst development
GO:0006508 proteolysis
GO:0007520 myoblast fusion
GO:0016540 protein autoprocessing
GO:0051493 regulation of cytoskeleton organization
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0000785 chromatin
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030425 dendrite
GO:0030864 cortical actin cytoskeleton
GO:0031143 pseudopodium
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
GO:0097038 perinuclear endoplasmic reticulum
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026509
View Gene Order
ENSBTAG00000012778
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04210
Apoptosis pathway
hsa05010
Alzheimer's disease pathway
hsa04510
Focal adhesion pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
fak_pathway
Signaling events mediated by focal adhesion kinase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.350899
RefSeq NM_001146068 NM_001748
HUGO
OMIM
CCDS CCDS31035 CCDS53478
HPRD 00254
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca