Version 5.4
Homo sapiens Gene: TRIM11
Summary
InnateDB Gene IDBG-107245.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM11
Gene Name tripartite motif containing 11
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154370
Encoded Proteins
IDBP-107249
tripartite motif containing 11
IDBP-107251
tripartite motif containing 11
IDBP-807089
tripartite motif containing 11
IDBP-807093
tripartite motif containing 11
IDBP-807094
tripartite motif containing 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:228393673-228406840
Strand Reverse strand
Band q42.13
Transcripts
ENST00000284551 ENSP00000284551
ENST00000366699 ENSP00000355660
ENST00000493030 ENSP00000473360
ENST00000475775
ENST00000602582 ENSP00000473574
ENST00000602308 ENSP00000473579
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0019904 protein domain specific binding
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0032897 negative regulation of viral transcription
GO:0045087 innate immune response
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046597 negative regulation of viral entry into host cell
GO:0046598 positive regulation of viral entry into host cell
GO:0050768 negative regulation of neurogenesis
GO:0051607 defense response to virus
GO:1902187 negative regulation of viral release from host cell
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020455
View Gene Order
ENSBTAG00000039246
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q96F44
TrEMBL
UniProt Splice Variant
Entrez Gene 81559
UniGene
RefSeq NM_145214
HUGO HGNC:16281
OMIM 607868
CCDS CCDS31048
HPRD 07429
IMGT
EMBL AF220125 AF327056 AK074866 AK097825 AK301859 AK314539 AL670729 BC011629 BC069227
GenPept AAG53498 AAH11629 AAH69227 AAM63957 BAC11254 BAG37129 BAG53535 BAG63300 CAH71671 CAH71672
RNA Seq Atlas 81559

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca