InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHRM3

Summary

InnateDB Gene

IDBG-107659.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHRM3

Gene Name

cholinergic receptor, muscarinic 3

Synonyms

EGBRS; HM3

Species

Homo sapiens

Ensembl Gene

ENSG00000133019

Encoded Proteins

IDBP-107663

cholinergic receptor, muscarinic 3

IDBP-390173

cholinergic receptor, muscarinic 3

IDBP-808234

cholinergic receptor, muscarinic 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:239386565-239915452

Strand

Forward strand

Band

q43

Transcripts

ENST00000255380	ENSP00000255380
ENST00000448020	ENSP00000404764
ENST00000468573
ENST00000492335
ENST00000481779
ENST00000487470
ENST00000615928	ENSP00000482377

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0016907	G-protein coupled acetylcholine receptor activity
GO:0042166	acetylcholine binding

Biological Process

GO:0003056	regulation of vascular smooth muscle contraction
GO:0006112	energy reserve metabolic process
GO:0006464	cellular protein modification process
GO:0006939	smooth muscle contraction
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0007399	nervous system development
GO:0007586	digestion
GO:0008283	cell proliferation
GO:0019229	regulation of vasoconstriction
GO:0044281	small molecule metabolic process
GO:0045987	positive regulation of smooth muscle contraction
GO:0046541	saliva secretion
GO:0050796	regulation of insulin secretion

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032279	asymmetric synapse
GO:0043679	axon terminus
GO:0045211	postsynaptic membrane