Homo sapiens Gene: GARS
Summary
InnateDB Gene IDBG-11151.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GARS
Gene Name glycyl-tRNA synthetase
Synonyms CMT2D; DSMAV; GlyRS; HMN5; SMAD1;
Species Homo sapiens
Ensembl Gene ENSG00000106105
Encoded Proteins
glycyl-tRNA synthetase
glycyl-tRNA synthetase
glycyl-tRNA synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:30594681-30634033
Strand Forward strand
Band p14.3
Transcripts
ENST00000389266 ENSP00000373918
ENST00000454308 ENSP00000392677
ENST00000444666 ENSP00000415447
ENST00000478124
ENST00000484093
ENST00000470392
ENST00000465748
ENST00000485784
ENST00000496643
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
Experimentally validated
Total 62 [view]
Protein-Protein 60 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004820 glycine-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006426 glycyl-tRNA aminoacylation
GO:0008219 cell death
GO:0010467 gene expression
GO:0015966 diadenosine tetraphosphate biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0030141 secretory granule
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cytosolic tRNA aminoacylation pathway
Mitochondrial tRNA aminoacylation pathway
tRNA Aminoacylation pathway
Gene Expression pathway
KEGG
Aminoacyl-tRNA biosynthesis pathway
INOH
Glycine Serine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P41250
TrEMBL F8WCK4 H7C443 Q75MN1
UniProt Splice Variant
Entrez Gene 2617
UniGene Hs.404321
RefSeq NM_002047 XM_006715686
HUGO HGNC:4162
OMIM 600287
CCDS CCDS43564
HPRD
IMGT
EMBL AC004976 AC005154 AC006969 AK074524 AK295490 BC007722 BC007755 D30658 U09510 U09587
GenPept AAA57001 AAA86443 AAC71652 AAH07722 AAH07755 AAS00367 BAA06338 BAG51964 BAG58412
RNA Seq Atlas 2617