InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LPCAT1

Summary

InnateDB Gene

IDBG-11200.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPCAT1

Gene Name

lysophosphatidylcholine acyltransferase 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000153395

Encoded Proteins

IDBP-11202

lysophosphatidylcholine acyltransferase 1

IDBP-480884

lysophosphatidylcholine acyltransferase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Lysophosphatidylcholine (LPC) acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis (Nakanishi et al., 2006 [PubMed 16704971]).[supplied by OMIM, May 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:1456480-1523977

Strand

Reverse strand

Band

p15.33

Transcripts

ENST00000283415	ENSP00000283415
ENST00000475622	ENSP00000423472
ENST00000503252
ENST00000513757
ENST00000514484
ENST00000507282

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0016746	transferase activity, transferring acyl groups
GO:0047159	1-alkenylglycerophosphocholine O-acyltransferase activity
GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity
GO:0047191	1-alkylglycerophosphocholine O-acyltransferase activity
GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0008152	metabolic process
GO:0008654	phospholipid biosynthetic process
GO:0019432	triglyceride biosynthetic process
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0043129	surfactant homeostasis
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045732	positive regulation of protein catabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0060041	retina development in camera-type eye
GO:2001246	negative regulation of phosphatidylcholine biosynthetic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005811	lipid particle
GO:0016020	membrane
GO:0016021	integral component of membrane