Version 5.4
Homo sapiens Gene: CLDN6
Summary
InnateDB Gene IDBG-11315.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLDN6
Gene Name claudin 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000184697
Encoded Proteins
IDBP-11317
claudin 6
IDBP-236483
claudin 6
IDBP-748168
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:3014712-3020071
Strand Reverse strand
Band p13.3
Transcripts
ENST00000328796 ENSP00000328674
ENST00000396925 ENSP00000380131
ENST00000572154 ENSP00000458783
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0016338 calcium-independent cell-cell adhesion
GO:0045216 cell-cell junction organization
Cellular Component
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023906
View Gene Order
ENSBTAG00000045901
Not yet available
Pathways
NETPATH
REACTOME
REACT_19373
Tight junction interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt P56747
TrEMBL
UniProt Splice Variant
Entrez Gene 9074
UniGene Hs.533779 Hs.690156
RefSeq NM_021195
HUGO HGNC:2048
OMIM 615798
CCDS CCDS10488
HPRD 13070
IMGT
EMBL AF125306 AJ249735 AK075329 AY358480 BC008934 BT007399 CH471112
GenPept AAH08934 AAK02013 AAP36063 AAQ88844 BAG52111 CAB56533 EAW85431 EAW85432
RNA Seq Atlas 9074

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca