Homo sapiens Gene: TNFRSF12A
Summary
InnateDB Gene IDBG-11328.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF12A
Gene Name tumor necrosis factor receptor superfamily, member 12A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000006327
Encoded Proteins
tumor necrosis factor receptor superfamily, member 12A
tumor necrosis factor receptor superfamily, member 12A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
The FN14 cytoplasmic tail binds to tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:3018445-3022383
Strand Forward strand
Band p13.3
Transcripts
ENST00000326577 ENSP00000326737
ENST00000341627 ENSP00000343894
ENST00000575124 ENSP00000460610
ENST00000574699 ENSP00000458305
ENST00000575836 ENSP00000461756
ENST00000573001 ENSP00000458898
ENST00000571351
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0006915 apoptotic process
GO:0006931 substrate-dependent cell migration, cell attachment to substrate
GO:0007155 cell adhesion
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045765 regulation of angiogenesis
GO:0045773 positive regulation of axon extension
GO:0061041 regulation of wound healing
GO:0097191 extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0001726 ruffle
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
TWEAK pathway
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_016639
HUGO
OMIM
CCDS CCDS10489
HPRD 05801
IMGT
EMBL
GenPept
RNA Seq Atlas