Version 5.4
Homo sapiens Gene: TNFRSF12A
Summary
InnateDB Gene IDBG-11328.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF12A
Gene Name tumor necrosis factor receptor superfamily, member 12A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000006327
Encoded Proteins
IDBP-11330
tumor necrosis factor receptor superfamily, member 12A
IDBP-11332
tumor necrosis factor receptor superfamily, member 12A
IDBP-750461
IDBP-750890
IDBP-751488
IDBP-750432
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 12529173
The FN14 cytoplasmic tail binds to tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:3018445-3022383
Strand Forward strand
Band p13.3
Transcripts
ENST00000326577 ENSP00000326737
ENST00000341627 ENSP00000343894
ENST00000575124 ENSP00000460610
ENST00000574699 ENSP00000458305
ENST00000575836 ENSP00000461756
ENST00000573001 ENSP00000458898
ENST00000571351
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0006915 apoptotic process
GO:0006931 substrate-dependent cell migration, cell attachment to substrate
GO:0007155 cell adhesion
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045765 regulation of angiogenesis
GO:0045773 positive regulation of axon extension
GO:0061041 regulation of wound healing
GO:0097191 extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0001726 ruffle
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
NetPath_26
TWEAK pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt Q9NP84
TrEMBL I3L0S4 I3L1J9 I3L3P4 I3L539
UniProt Splice Variant
Entrez Gene 51330
UniGene
RefSeq NM_016639
HUGO HGNC:18152
OMIM 605914
CCDS CCDS10489
HPRD
IMGT
EMBL AB035480 AB035481 AC108134 AF191148 BC002718 CH471112
GenPept AAF69108 AAH02718 BAA94792 BAB17850 EAW85429 EAW85430
RNA Seq Atlas 51330

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca