Version 5.4
Homo sapiens Gene: COPS2
Summary
InnateDB Gene IDBG-11343.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COPS2
Gene Name COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
Synonyms ALIEN; CSN2; SGN2; TRIP15
Species Homo sapiens
Ensembl Gene ENSG00000166200
Encoded Proteins
IDBP-11345
COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
IDBP-11349
COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
IDBP-585929
COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
IDBP-598117
COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
IDBP-584322
COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
IDBP-601564
COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 15:49106068-49155661
Strand Reverse strand
Band q21.1
Transcripts
ENST00000299259 ENSP00000299259
ENST00000388901 ENSP00000373553
ENST00000560240 ENSP00000453546
ENST00000542928 ENSP00000443664
ENST00000558843 ENSP00000452944
ENST00000561248 ENSP00000453412
ENST00000559016
ENST00000558545
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 141 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 141 [view]
Protein-Protein 139 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0010388 cullin deneddylation
GO:0030182 neuron differentiation
GO:0035914 skeletal muscle cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027206
View Gene Order
ENSBTAG00000013425
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H0YMC2
UniProt Splice Variant
Entrez Gene 9318
UniGene Hs.369614 Hs.602481 Hs.609640
RefSeq NM_001143887 NM_004236
HUGO HGNC:30747
OMIM 604508
CCDS CCDS32235 CCDS45257
HPRD 05146
IMGT
EMBL AC013452
GenPept
RNA Seq Atlas 9318

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca