Homo sapiens Gene: ADRA2C
Summary
InnateDB Gene IDBG-114355.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADRA2C
Gene Name adrenoceptor alpha 2C
Synonyms ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR;
Species Homo sapiens
Ensembl Gene ENSG00000184160
Encoded Proteins
adrenergic, alpha-2C-, receptor
adrenergic, alpha-2C-, receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:3766348-3768526
Strand Forward strand
Band p16.3
Transcripts
ENST00000330055 ENSP00000386069
ENST00000509482 ENSP00000426268
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004938 alpha2-adrenergic receptor activity
GO:0005515 protein binding
GO:0031694 alpha-2A adrenergic receptor binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0051379 epinephrine binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0006940 regulation of smooth muscle contraction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007565 female pregnancy
GO:0007596 blood coagulation
GO:0010700 negative regulation of norepinephrine secretion
GO:0019229 regulation of vasoconstriction
GO:0030168 platelet activation
GO:0032148 activation of protein kinase B activity
GO:0032811 negative regulation of epinephrine secretion
GO:0035625 epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0044281 small molecule metabolic process
GO:0045666 positive regulation of neuron differentiation
GO:0045907 positive regulation of vasoconstriction
GO:0050796 regulation of insulin secretion
GO:0051930 regulation of sensory perception of pain
GO:0070473 negative regulation of uterine smooth muscle contraction
GO:0071875 adrenergic receptor signaling pathway
GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0043679 axon terminus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Integration of energy metabolism pathway
Class A/1 (Rhodopsin-like receptors) pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
Amine ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
G alpha (z) signalling events pathway
Platelet Aggregation (Plug Formation) pathway
Adrenoceptors pathway
Adrenaline signalling through Alpha-2 adrenergic receptor pathway
GPCR ligand binding pathway
Regulation of insulin secretion pathway
Metabolism pathway
Hemostasis pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.123022
RefSeq NM_000683
HUGO
OMIM
CCDS CCDS47004
HPRD 00085
IMGT
EMBL
GenPept
RNA Seq Atlas