InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADRA2C

Summary

InnateDB Gene

IDBG-114355.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRA2C

Gene Name

adrenoceptor alpha 2C

Synonyms

ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR

Species

Homo sapiens

Ensembl Gene

ENSG00000184160

Encoded Proteins

IDBP-292598

adrenergic, alpha-2C-, receptor

IDBP-481179

adrenergic, alpha-2C-, receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:3766348-3768526

Strand

Forward strand

Band

p16.3

Transcripts

ENST00000330055	ENSP00000386069
ENST00000509482	ENSP00000426268

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004938	alpha2-adrenergic receptor activity
GO:0005515	protein binding
GO:0031694	alpha-2A adrenergic receptor binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051379	epinephrine binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006940	regulation of smooth muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007565	female pregnancy
GO:0007596	blood coagulation
GO:0010700	negative regulation of norepinephrine secretion
GO:0019229	regulation of vasoconstriction
GO:0030168	platelet activation
GO:0032148	activation of protein kinase B activity
GO:0032811	negative regulation of epinephrine secretion
GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0044281	small molecule metabolic process
GO:0045666	positive regulation of neuron differentiation
GO:0045907	positive regulation of vasoconstriction
GO:0050796	regulation of insulin secretion
GO:0051930	regulation of sensory perception of pain
GO:0070473	negative regulation of uterine smooth muscle contraction
GO:0071875	adrenergic receptor signaling pathway
GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043679	axon terminus