Version 5.4
Homo sapiens Gene: PPP1R17
Summary
InnateDB Gene IDBG-11547.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R17
Gene Name protein phosphatase 1, regulatory subunit 17
Synonyms C7orf16; GSBS
Species Homo sapiens
Ensembl Gene ENSG00000106341
Encoded Proteins
IDBP-11549
protein phosphatase 1, regulatory subunit 17
IDBP-294413
protein phosphatase 1, regulatory subunit 17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:31686715-31708455
Strand Forward strand
Band p14.3
Transcripts
ENST00000342032 ENSP00000340125
ENST00000409146 ENSP00000386459
ENST00000498609
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
GO:0004865 protein serine/threonine phosphatase inhibitor activity
GO:0019212 phosphatase inhibitor activity
Biological Process
GO:0007417 central nervous system development
GO:0010921 regulation of phosphatase activity
GO:0035556 intracellular signal transduction
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002930
View Gene Order
ENSBTAG00000001976
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04730
Long-term depression pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.227011 Hs.608660 Hs.615243
RefSeq NM_001145123 NM_006658
HUGO
OMIM
CCDS CCDS47570 CCDS5436
HPRD 06820
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca