Homo sapiens Gene: PPP1R17
Summary
InnateDB Gene IDBG-11547.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R17
Gene Name protein phosphatase 1, regulatory subunit 17
Synonyms C7orf16; GSBS;
Species Homo sapiens
Ensembl Gene ENSG00000106341
Encoded Proteins
protein phosphatase 1, regulatory subunit 17
protein phosphatase 1, regulatory subunit 17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:31686715-31708455
Strand Forward strand
Band p14.3
Transcripts
ENST00000342032 ENSP00000340125
ENST00000409146 ENSP00000386459
ENST00000498609
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
GO:0004865 protein serine/threonine phosphatase inhibitor activity
GO:0019212 phosphatase inhibitor activity
Biological Process
GO:0007417 central nervous system development
GO:0010921 regulation of phosphatase activity
GO:0035556 intracellular signal transduction
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Long-term depression pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O96001
TrEMBL
UniProt Splice Variant
Entrez Gene 10842
UniGene Hs.227011 Hs.608660 Hs.615243
RefSeq NM_001145123 NM_006658
HUGO HGNC:16973
OMIM 604088
CCDS CCDS47570 CCDS5436
HPRD
IMGT
EMBL AC006325 AF071789 AF097730 AK293478 BC028094
GenPept AAD12588 AAD13030 AAF03537 AAH28094 BAG56969
RNA Seq Atlas 10842