Version 5.4
Homo sapiens Gene: HIST3H2BB
Summary
InnateDB Gene IDBG-115825.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST3H2BB
Gene Name histone cluster 3, H2bb
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196890
Encoded Proteins
IDBP-246830
histone cluster 3, H2bb
IDBP-807282
histone cluster 3, H2bb
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:228458107-228460470
Strand Forward strand
Band q42.13
Transcripts
ENST00000369160 ENSP00000375736
ENST00000620438 ENSP00000479284
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000056895
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa05322
Systemic lupus erythematosus pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 128312
UniGene Hs.376691
RefSeq NM_175055 NM_003528
HUGO HGNC:20514
OMIM 615046
CCDS CCDS1574 CCDS936
HPRD
IMGT
EMBL AK091220 AL139288 AY131981 BC100855 BC100856 BC100857 BC100858 BC137467 BC137468 CH471098
GenPept AAI00856 AAI00857 AAI00858 AAI00859 AAI37468 AAI37469 AAN59962 BAC03613 CAI23330 EAW69879
RNA Seq Atlas 128312

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca