Version 5.4
Homo sapiens Gene: GABPB1
Summary
InnateDB Gene IDBG-11644.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABPB1
Gene Name GA binding protein transcription factor, beta subunit 1
Synonyms BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B; GABPB; GABPB2; NRF2B1; NRF2B2
Species Homo sapiens
Ensembl Gene ENSG00000104064
Encoded Proteins
IDBP-11646
GA binding protein transcription factor, beta subunit 1
IDBP-11648
GA binding protein transcription factor, beta subunit 1
IDBP-11650
GA binding protein transcription factor, beta subunit 1
IDBP-237432
GA binding protein transcription factor, beta subunit 1
IDBP-372433
GA binding protein transcription factor, beta subunit 1
IDBP-584934
GA binding protein transcription factor, beta subunit 1
IDBP-591114
GA binding protein transcription factor, beta subunit 1
IDBP-600096
GA binding protein transcription factor, beta subunit 1
IDBP-587729
GA binding protein transcription factor, beta subunit 1
IDBP-597183
GA binding protein transcription factor, beta subunit 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:50275392-50355408
Strand Reverse strand
Band q21.2
Transcripts
ENST00000380877 ENSP00000370259
ENST00000220429 ENSP00000220429
ENST00000359031 ENSP00000351923
ENST00000396464 ENSP00000379728
ENST00000429662 ENSP00000395771
ENST00000543881 ENSP00000442500
ENST00000561010 ENSP00000453806
ENST00000560825 ENSP00000453463
ENST00000559100
ENST00000558335 ENSP00000453578
ENST00000558970 ENSP00000454211
ENST00000615671
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 22 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000027361
View Gene Order
Cross-References
SwissProt Q06547
TrEMBL F5H7I4 H0YNZ0
UniProt Splice Variant
Entrez Gene 55056
UniGene Hs.654350
RefSeq NM_005254 XM_005254273 XM_005254274 XM_006720455 XM_006720456 NM_002041 NM_016654 NM_016655 NM_181427 XM_006720457 XM_006720458
HUGO HGNC:4074
OMIM 600610
CCDS CCDS32239 CCDS10135 CCDS10136 CCDS45258
HPRD 15975
IMGT
EMBL AC022087 BC016910 BC036080 BC050702 BT006652 CH471082 D13316 D13317 EU159454 U13045 U13046 U13047 U13048
GenPept AAA65707 AAA65708 AAA65709 AAA65710 AAH16910 AAH36080 AAH50702 AAP35298 ABV90874 BAA02573 BAA02574 EAW77395
RNA Seq Atlas 2553 55056

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca