Homo sapiens Gene: PKDREJ
Summary
InnateDB Gene IDBG-11888.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKDREJ
Gene Name polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130943
Encoded Proteins
polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This intronless gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a receptor for egg jelly (REJ) domain, a G-protein-coupled receptor proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may play a role in human reproduction. Alternative splice variants have been described but their biological natures have not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:46255663-46263355
Strand Reverse strand
Band q13.31
Transcripts
ENST00000253255 ENSP00000253255
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
GO:0007218 neuropeptide signaling pathway
GO:0007340 acrosome reaction
GO:0050982 detection of mechanical stimulus
GO:0055085 transmembrane transport
GO:0060046 regulation of acrosome reaction
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.241383 Hs.608983 Hs.609094
RefSeq NM_006071
HUGO
OMIM
CCDS CCDS14073
HPRD 05239
IMGT
EMBL
GenPept
RNA Seq Atlas