Version 5.4
Homo sapiens Gene: TRAP1
Summary
InnateDB Gene IDBG-12290.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAP1
Gene Name TNF receptor-associated protein 1
Synonyms HSP 75; HSP75; HSP90L; TRAP-1
Species Homo sapiens
Ensembl Gene ENSG00000126602
Encoded Proteins
IDBP-12292
TNF receptor-associated protein 1
IDBP-584521
TNF receptor-associated protein 1
IDBP-753035
IDBP-751765
IDBP-750290
IDBP-745685
IDBP-751832
IDBP-749710
IDBP-750714
IDBP-745078
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:3651639-3717597
Strand Reverse strand
Band p13.3
Transcripts
ENST00000246957 ENSP00000246957
ENST00000538171 ENSP00000442070
ENST00000574941
ENST00000573872
ENST00000574494
ENST00000571538 ENSP00000458244
ENST00000570514
ENST00000575854
ENST00000575671 ENSP00000458166
ENST00000571011 ENSP00000460545
ENST00000570403 ENSP00000461354
ENST00000575707 ENSP00000459385
ENST00000571804 ENSP00000461618
ENST00000574175 ENSP00000459585
ENST00000576788
ENST00000576106
ENST00000576335 ENSP00000459354
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 61 [view]
Protein-Protein 59 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0006950 response to stress
GO:1901856 negative regulation of cellular respiration
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005981
View Gene Order
ENSBTAG00000020109
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.30345
RefSeq NM_001272049 NM_016292
HUGO
OMIM
CCDS CCDS10508 CCDS61824
HPRD 05868
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca