Version 5.4
Homo sapiens Gene: IGHG4
Summary
InnateDB Gene IDBG-124361.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGHG4
Gene Name immunoglobulin heavy constant gamma 4 (G4m marker)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000211892
Encoded Proteins
IDBP-124365
immunoglobulin heavy constant gamma 4 (G4m marker)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type IG_C_gene
Genomic Location Chromosome 14:105624341-105626066
Strand Reverse strand
Band q32.33
Transcripts
ENST00000390543 ENSP00000374985
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003823 antigen binding
GO:0005515 protein binding
Biological Process
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0072562 blood microparticle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_160274
FCGR activation pathway
REACT_7956
Classical antibody-mediated complement activation pathway
REACT_8024
Initial triggering of complement pathway
REACT_6802
Innate Immune System pathway
REACT_8012
Creation of C4 and C2 activators pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_6932
Complement cascade pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P01861
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO HGNC:5528
OMIM 147130
CCDS
HPRD
IMGT IGHG4
EMBL AL928742 K01316
GenPept AAB59394
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca