InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GLIS2

Summary

InnateDB Gene

IDBG-12609.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLIS2

Gene Name

GLIS family zinc finger 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000126603

Encoded Proteins

IDBP-12611

GLIS family zinc finger 2

IDBP-367159

GLIS family zinc finger 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.[provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:4314761-4339597

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000262366	ENSP00000262366
ENST00000433375	ENSP00000395547

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007399	nervous system development
GO:0030154	cell differentiation
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045879	negative regulation of smoothened signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016607	nuclear speck

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000014303

View Gene Order

ENSBTAG00000009199

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.592087

RefSeq

NM_032575 XM_005255641 XM_005255642 XM_006725240 XM_006725241

HUGO

OMIM

CCDS

CCDS10511

HPRD

12256

IMGT

EMBL

GenPept

RNA Seq Atlas