|Homo sapiens Gene: MIR21|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||microRNA 21|
|Useful resources||Stemformatics EHFPI ImmGen|
MIR21 targets PDCD4, which acts a molecular switch between the pro-inflammatory (NFkB) and anti-inflammatory (IL10) response. MIR21-mediated reduction of PDCD4 is essential for protecting against the lethal effects of LPS.
MIR21 is upregulated during Mycobacterium leprae infection of monocytes to escape from vitamin D-dependent antimicrobial pathways.
Circulating MIR21 activates natural killer cells via the TLR1 signalling pathway.
MIR21 inhibition enhances CCL5 (RANTES) and CXCL10 (IP-10) release in MCF-7 cancer cells and resulted in increased lymphocyte migration . PIAS3 is a target of MIR21 in MCF-7 cells.
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|Genomic Location||Chromosome 17:59841266-59841337|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
|No orthologs found for this gene|
|UniProt Splice Variant|
|RNA Seq Atlas|