Version 5.4
Homo sapiens Gene: PRTN3
Summary
InnateDB Gene IDBG-13084.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRTN3
Gene Name proteinase 3
Synonyms ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3
Species Homo sapiens
Ensembl Gene ENSG00000196415
Encoded Proteins
IDBP-13086
proteinase 3
IDBP-811471
proteinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 24129891
IL32 interacts with PRTN2 (PR3) and F2RL1, triggering the PAR2-TRIF signalling axis, and IL32 may have a potential role in the transition from innate to adaptive immunity.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:840960-848175
Strand Forward strand
Band p13.3
Transcripts
ENST00000234347 ENSP00000234347
ENST00000544537 ENSP00000475174
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0019899 enzyme binding
Biological Process
GO:0006508 proteolysis
GO:0008284 positive regulation of cell proliferation
GO:0030574 collagen catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0050765 negative regulation of phagocytosis
GO:0097029 mature dendritic cell differentiation
Cellular Component
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057729
View Gene Order
ENSBTAG00000046105
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.731783 Hs.928
RefSeq NM_002777
HUGO
OMIM
CCDS CCDS32860
HPRD 01512
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca