InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Myo10

Summary

InnateDB Gene

IDBG-130902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo10

Gene Name

myosin X

Synonyms

AW048724; D15Ertd600e; mKIAA0799

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022272

Encoded Proteins

IDBP-130906

myosin X

IDBP-260177

myosin X

IDBP-541048

myosin X

IDBP-535385

myosin X

IDBP-538961

myosin X

IDBP-536860

myosin X

IDBP-533238

myosin X

IDBP-533307

myosin X

IDBP-532414

myosin X

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145555:
This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:25622525-25813673

Strand

Forward strand

Band

Transcripts

ENSMUST00000022882	ENSMUSP00000022882
ENSMUST00000110457	ENSMUSP00000106087
ENSMUST00000137601	ENSMUSP00000118280
ENSMUST00000127486
ENSMUST00000130517
ENSMUST00000126076
ENSMUST00000135981	ENSMUSP00000123057
ENSMUST00000135173	ENSMUSP00000118744
ENSMUST00000131834	ENSMUSP00000119200
ENSMUST00000124966	ENSMUSP00000120817
ENSMUST00000151360	ENSMUSP00000119367
ENSMUST00000125667	ENSMUSP00000120566
ENSMUST00000145587

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0030507	spectrin binding
GO:0030898	actin-dependent ATPase activity
GO:0051015	actin filament binding
GO:0060002	plus-end directed microfilament motor activity

Biological Process

GO:0006200	ATP catabolic process
GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0008360	regulation of cell shape
GO:0022409	positive regulation of cell-cell adhesion
GO:0030705	cytoskeleton-dependent intracellular transport
GO:0048870	cell motility
GO:0051489	regulation of filopodium assembly

Cellular Component

GO:0001726	ruffle
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016459	myosin complex
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0031527	filopodium membrane
GO:0032433	filopodium tip
GO:0043005	neuron projection
GO:0043025	neuronal cell body