Version 5.4
Mus musculus Gene: Cst6
Summary
InnateDB Gene IDBG-131307.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cst6
Gene Name cystatin E/M
Synonyms 1110017E11Rik; ichq; N28197
Species Mus musculus
Ensembl Gene ENSMUSG00000024846
Encoded Proteins
IDBP-131309
cystatin E/M
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175315:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:5344705-5349574
Strand Reverse strand
Band A
Transcripts
ENSMUST00000025764 ENSMUSP00000025764
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
Biological Process
GO:0008544 epidermis development
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0001533 cornified envelope
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000175315
View Gene Order
Cross-References
SwissProt
TrEMBL Q8K397 Q9D1B1
UniProt Splice Variant
Entrez Gene 73720
UniGene Mm.36816
RefSeq NM_028623
OMIM
CCDS CCDS29457
HPRD
IMGT
MGI ID MGI:1920970
MGI Symbol Cst6
EMBL AC122861 AK003744 AK078116 AY093591 BC027680 BC061036 CH466612
GenPept AAH27680 AAH61036 AAM11475 BAB22976 BAC37132 EDL33113
RNA Seq Atlas 73720

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca