Mus musculus Gene: Ccnc
Summary
InnateDB Gene IDBG-131508.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccnc
Gene Name cyclin C
Synonyms AI451004; AU020987; CG1C;
Species Mus musculus
Ensembl Gene ENSMUSG00000028252
Encoded Proteins
cyclin C
cyclin C
cyclin C
cyclin C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112237:
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:21727701-21759922
Strand Forward strand
Band A3
Transcripts
ENSMUST00000065928 ENSMUSP00000069076
ENSMUST00000102997 ENSMUSP00000100062
ENSMUST00000108240 ENSMUSP00000103875
ENSMUST00000120679 ENSMUSP00000113682
ENSMUST00000133597
ENSMUST00000123294
ENSMUST00000145288
ENSMUST00000133712
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005654 nucleoplasm
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0016592 mediator complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Transcriptional regulation of white adipocyte differentiation pathway
Mus musculus biological processes pathway
Disease pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Loss of Function of SMAD4 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Loss of Function of TGFBR2 in Cancer pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Gene Expression pathway
PPARA activates gene expression pathway
Developmental Biology pathway
Loss of Function of TGFBR1 in Cancer pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Generic Transcription Pathway pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
Signaling by NOTCH pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Developmental Biology pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Metabolism of lipids and lipoproteins pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signaling by NOTCH1 in Cancer pathway
PPARA activates gene expression pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Generic Transcription Pathway pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
TGFBR1 KD Mutants in Cancer pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Transcriptional regulation of white adipocyte differentiation pathway
Metabolism pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Gene Expression pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Generic Transcription Pathway pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Signaling by NOTCH pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Loss of Function of TGFBR2 in Cancer pathway
Gene Expression pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Transcriptional regulation of white adipocyte differentiation pathway
Signaling by NOTCH1 in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Signal Transduction pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Signaling by NOTCH1 pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
PPARA activates gene expression pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Loss of Function of SMAD2/3 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Disease pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
Developmental Biology pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.278584 Mm.400278 Mm.403175
RefSeq NM_001122982 NM_001290420 NM_001290422 NM_016746 XM_006538076 XM_006538077 XM_006538078 XM_006538079 XM_006538081 XM_006538082
OMIM
CCDS CCDS17998 CCDS51127 CCDS71350
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas