Version 5.4
Mus musculus Gene: Car1
Summary
InnateDB Gene IDBG-131948.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Car1
Gene Name carbonic anhydrase 1
Synonyms AW555628; Ca1; Car-1
Species Mus musculus
Ensembl Gene ENSMUSG00000027556
Encoded Proteins
IDBP-131952
carbonic anhydrase 1
IDBP-536868
carbonic anhydrase 1
IDBP-717766
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133742:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Variants of this gene have been described in some populations. Multiple alternatively spliced variants, encoding the same protein, have been identified. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature. [provided by RefSeq, Sep 2009]
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:14766216-14808368
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000094365 ENSMUSP00000091925
ENSMUST00000144327 ENSMUSP00000120495
ENSMUST00000181860 ENSMUSP00000137926
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006730 one-carbon metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000133742
View Gene Order
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_199096
Reversible hydration of carbon dioxide pathway
REACT_199094
Erythrocytes take up carbon dioxide and release oxygen pathway
REACT_199095
O2/CO2 exchange in erythrocytes pathway
REACT_199098
Erythrocytes take up oxygen and release carbon dioxide pathway
KEGG
mmu00910
Nitrogen metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121123
Reversible hydration of carbon dioxide pathway
REACT_121380
Erythrocytes take up oxygen and release carbon dioxide pathway
REACT_121329
Erythrocytes take up carbon dioxide and release oxygen pathway
REACT_120969
O2/CO2 exchange in erythrocytes pathway
REACT_111217
Metabolism pathway
KEGG
hsa00910
Nitrogen metabolism pathway
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt P13634
TrEMBL
UniProt Splice Variant
Entrez Gene 12346
UniGene Mm.465885
RefSeq NM_001083957 XM_006530049 NM_009799
OMIM
CCDS CCDS17248
HPRD
IMGT
MGI ID MGI:88268
MGI Symbol Car1
EMBL AC167976 AK003066 AK146372 AK162331 AK167969 AK172076 BC011223 BC110681 BC132432 BC132434 CH466577 L36650 L36651 L36652 L36653 L36654 L36655 M28197 M32452
GenPept AAA37354 AAA50291 AAH11223 AAI10682 AAI32433 AAI32435 BAB22544 BAE27121 BAE36857 BAE39964 BAE42813 EDL05133
RNA Seq Atlas 12346

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca