Mus musculus Gene: Car1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-131948.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Car1 | ||||||||||||||||||||||
Gene Name | carbonic anhydrase 1 | ||||||||||||||||||||||
Synonyms | AW555628; Ca1; Car-1 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000027556 | ||||||||||||||||||||||
Encoded Proteins |
carbonic anhydrase 1
carbonic anhydrase 1
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Protein Structure |
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Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133742:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Variants of this gene have been described in some populations. Multiple alternatively spliced variants, encoding the same protein, have been identified. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature. [provided by RefSeq, Sep 2009] Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 3:14766216-14808368 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | A1 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Metabolism pathway
Reversible hydration of carbon dioxide pathway
Erythrocytes take up carbon dioxide and release oxygen pathway
O2/CO2 exchange in erythrocytes pathway
Erythrocytes take up oxygen and release carbon dioxide pathway
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KEGG |
Nitrogen metabolism pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Reversible hydration of carbon dioxide pathway
Erythrocytes take up oxygen and release carbon dioxide pathway
Erythrocytes take up carbon dioxide and release oxygen pathway
O2/CO2 exchange in erythrocytes pathway
Metabolism pathway
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KEGG |
Nitrogen metabolism pathway
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INOH | |||||||||||||||||||||||
PID NCI |
C-MYB transcription factor network
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Cross-References | |||||||||||||||||||||||
SwissProt | P13634 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 12346 | ||||||||||||||||||||||
UniGene | Mm.465885 | ||||||||||||||||||||||
RefSeq | NM_001083957 XM_006530049 NM_009799 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS17248 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:88268 | ||||||||||||||||||||||
MGI Symbol | Car1 | ||||||||||||||||||||||
EMBL | AC167976 AK003066 AK146372 AK162331 AK167969 AK172076 BC011223 BC110681 BC132432 BC132434 CH466577 L36650 L36651 L36652 L36653 L36654 L36655 M28197 M32452 | ||||||||||||||||||||||
GenPept | AAA37354 AAA50291 AAH11223 AAI10682 AAI32433 AAI32435 BAB22544 BAE27121 BAE36857 BAE39964 BAE42813 EDL05133 | ||||||||||||||||||||||
RNA Seq Atlas | 12346 | ||||||||||||||||||||||