InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Arhgef7

Summary

InnateDB Gene

IDBG-132947.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgef7

Gene Name

Rho guanine nucleotide exchange factor (GEF7)

Synonyms

betaPix; betaPix-b; betaPix-c; Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031511

Encoded Proteins

IDBP-132949

Rho guanine nucleotide exchange factor (GEF7)

IDBP-132951

Rho guanine nucleotide exchange factor (GEF7)

IDBP-132953

Rho guanine nucleotide exchange factor (GEF7)

IDBP-259242

Rho guanine nucleotide exchange factor (GEF7)

IDBP-259244

Rho guanine nucleotide exchange factor (GEF7)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102606:
Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:11728105-11835219

Strand

Forward strand

Band

A1.1

Transcripts

ENSMUST00000033908	ENSMUSP00000033908
ENSMUST00000074856	ENSMUSP00000074399
ENSMUST00000098938	ENSMUSP00000096538
ENSMUST00000110909	ENSMUSP00000106534
ENSMUST00000110904	ENSMUSP00000106529
ENSMUST00000154204
ENSMUST00000151225

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0007399	nervous system development
GO:0030032	lamellipodium assembly
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0001726	ruffle
GO:0005925	focal adhesion
GO:0005938	cell cortex
GO:0030027	lamellipodium
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043234	protein complex