Version 5.4
Mus musculus Gene: Stxbp5
Summary
InnateDB Gene IDBG-133108.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stxbp5
Gene Name syntaxin binding protein 5 (tomosyn)
Synonyms 0710001E20Rik; 4930565N16Rik; AW742610; LGL3; mKIAA1006
Species Mus musculus
Ensembl Gene ENSMUSG00000019790
Encoded Proteins
IDBP-133110
syntaxin binding protein 5 (tomosyn)
IDBP-538451
syntaxin binding protein 5 (tomosyn)
IDBP-537464
syntaxin binding protein 5 (tomosyn)
IDBP-532860
syntaxin binding protein 5 (tomosyn)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164506:
Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:9755547-9901079
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000038213 ENSMUSP00000044535
ENSMUST00000141722 ENSMUSP00000123253
ENSMUST00000151435
ENSMUST00000136259
ENSMUST00000125200 ENSMUSP00000121507
ENSMUST00000131828
ENSMUST00000148009
ENSMUST00000139199
ENSMUST00000136324 ENSMUSP00000123355
ENSMUST00000128487
ENSMUST00000139779
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017075 syntaxin-1 binding
GO:0019905 syntaxin binding
Biological Process
GO:0006887 exocytosis
GO:0007409 axonogenesis
GO:0010468 regulation of gene expression
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0017157 regulation of exocytosis
GO:0030193 regulation of blood coagulation
GO:0045921 positive regulation of exocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0005892 acetylcholine-gated channel complex
GO:0016021 integral component of membrane
GO:0030141 secretory granule
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164506
View Gene Order
ENSBTAG00000021107
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.411099 Mm.473447
RefSeq NM_001081344 XM_006512926
OMIM
CCDS CCDS35837
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca