InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Snx9

Summary

InnateDB Gene

IDBG-133136.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snx9

Gene Name

sorting nexin 9

Synonyms

2700073N08Rik; SDP1; SH3PX1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002365

Encoded Proteins

IDBP-133138

sorting nexin 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130340:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain a SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:5841328-5931033

Strand

Forward strand

Band

Transcripts

ENSMUST00000002436

ENSMUSP00000002436

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005545	1-phosphatidylinositol binding
GO:0031625	ubiquitin protein ligase binding
GO:0035091	phosphatidylinositol binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000281	mitotic cytokinesis
GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0006898	receptor-mediated endocytosis
GO:0007067	mitotic nuclear division
GO:0015031	protein transport
GO:0016197	endosomal transport
GO:0032461	positive regulation of protein oligomerization
GO:0036089	cleavage furrow formation
GO:0043547	positive regulation of GTPase activity
GO:0060988	lipid tube assembly

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030136	clathrin-coated vesicle
GO:0030659	cytoplasmic vesicle membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000130340

View Gene Order

ENSBTAG00000006323

Not yet available

Pathways

NETPATH

REACTOME

REACT_209837

Membrane Trafficking pathway

REACT_232671

Golgi Associated Vesicle Biogenesis pathway

REACT_243409

trans-Golgi Network Vesicle Budding pathway

REACT_234979

Clathrin derived vesicle budding pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19400

Golgi Associated Vesicle Biogenesis pathway

REACT_19187

Clathrin derived vesicle budding pathway

REACT_11235

trans-Golgi Network Vesicle Budding pathway

REACT_11123

Membrane Trafficking pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q91VH2

TrEMBL

Q3U1P2

UniProt Splice Variant

Entrez Gene

66616

UniGene

Mm.319513 Mm.89515

RefSeq

NM_025664 XM_006523241

OMIM

CCDS

CCDS57041

HPRD

IMGT

MGI ID

MGI:1913866

MGI Symbol

Snx9

EMBL

AK149849 AK155830 AK170339 BC014814

GenPept

AAH14814 BAE29121 BAE33453 BAE41729

RNA Seq Atlas

66616