InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KISS1R

Summary

InnateDB Gene

IDBG-13327.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KISS1R

Gene Name

KISS1 receptor

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000116014

Encoded Proteins

IDBP-13329

KISS1 receptor

IDBP-761711

IDBP-812888

KISS1 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:917287-921015

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000234371	ENSP00000234371
ENST00000592648	ENSP00000467666
ENST00000606939	ENSP00000475639

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008188	neuropeptide receptor activity
GO:0008528	G-protein coupled peptide receptor activity
GO:0042923	neuropeptide binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0019722	calcium-mediated signaling
GO:0046887	positive regulation of hormone secretion
GO:0050482	arachidonic acid secretion
GO:0050806	positive regulation of synaptic transmission
GO:0051496	positive regulation of stress fiber assembly

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000035773

View Gene Order

ENSBTAG00000037418

Not yet available

Pathways

NETPATH

REACTOME

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.208229

RefSeq

NM_032551

HUGO

OMIM

CCDS

CCDS12049

HPRD

09167

IMGT

EMBL

GenPept

RNA Seq Atlas