InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ESRRB

Summary

InnateDB Gene

IDBG-13343.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ESRRB

Gene Name

estrogen-related receptor beta

Synonyms

DFNB35; ERR2; ERRb; ESRL2; NR3B2

Species

Homo sapiens

Ensembl Gene

ENSG00000119715

Encoded Proteins

IDBP-13347

estrogen-related receptor beta

IDBP-479538

estrogen-related receptor beta

IDBP-473532

estrogen-related receptor beta

IDBP-477602

estrogen-related receptor beta

IDBP-585544

estrogen-related receptor beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:76310614-76501841

Strand

Forward strand

Band

q24.3

Transcripts

ENST00000380887	ENSP00000370270
ENST00000512784	ENSP00000424992
ENST00000505752	ENSP00000423004
ENST00000507951
ENST00000509242	ENSP00000422488
ENST00000509323
ENST00000556177	ENSP00000451658
ENST00000611036

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	96 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003713	transcription coactivator activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001831	trophectodermal cellular morphogenesis
GO:0001834	trophectodermal cell proliferation
GO:0001892	embryonic placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0019827	stem cell maintenance
GO:0030522	intracellular receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021255

View Gene Order

ENSBTAG00000012285

Not yet available

Pathways

NETPATH

REACTOME

REACT_15525

Nuclear Receptor transcription pathway pathway

REACT_12627

Generic Transcription Pathway pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.435845

RefSeq

NM_004452 XM_005267404 XM_006720077 XM_006720078

HUGO

OMIM

CCDS

CCDS9850

HPRD

03700

IMGT

EMBL

GenPept

RNA Seq Atlas