Homo sapiens Gene: ESRRB
Summary
InnateDB Gene IDBG-13343.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ESRRB
Gene Name estrogen-related receptor beta
Synonyms DFNB35; ERR2; ERRb; ESRL2; NR3B2;
Species Homo sapiens
Ensembl Gene ENSG00000119715
Encoded Proteins
estrogen-related receptor beta
estrogen-related receptor beta
estrogen-related receptor beta
estrogen-related receptor beta
estrogen-related receptor beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:76310614-76501841
Strand Forward strand
Band q24.3
Transcripts
ENST00000380887 ENSP00000370270
ENST00000512784 ENSP00000424992
ENST00000505752 ENSP00000423004
ENST00000507951
ENST00000509242 ENSP00000422488
ENST00000509323
ENST00000556177 ENSP00000451658
ENST00000611036
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 96 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003713 transcription coactivator activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005496 steroid binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001831 trophectodermal cellular morphogenesis
GO:0001834 trophectodermal cell proliferation
GO:0001892 embryonic placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0019827 stem cell maintenance
GO:0030522 intracellular receptor signaling pathway
GO:0043401 steroid hormone mediated signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Nuclear Receptor transcription pathway pathway
Generic Transcription Pathway pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O95718
TrEMBL Q9HCB2
UniProt Splice Variant
Entrez Gene 2103
UniGene Hs.435845
RefSeq NM_004452 XM_005267404 XM_006720077 XM_006720078
HUGO HGNC:3473
OMIM 602167
CCDS CCDS9850
HPRD 03700
IMGT
EMBL AB307714 AC008050 AC016543 AF094517 AY451389 AY451390 BC131517 HQ692852
GenPept AAC99409 AAG17472 AAG29619 AAI31518 AAS15571 AAS15572 ADZ17363 BAH02305
RNA Seq Atlas 2103