Mus musculus Gene: Pgr
Summary
InnateDB Gene IDBG-133652.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pgr
Gene Name progesterone receptor
Synonyms 9930019P03Rik; BB114106; ENSMUSG00000074510; NR3C3; PR; PR-A; PR-B;
Species Mus musculus
Ensembl Gene ENSMUSG00000031870
Encoded Proteins
progesterone receptor
progesterone receptor
progesterone receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000082175:
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:8899833-8968611
Strand Forward strand
Band A1
Transcripts
ENSMUST00000070463 ENSMUSP00000063562
ENSMUST00000098986 ENSMUSP00000096584
ENSMUST00000151080
ENSMUST00000189181 ENSMUSP00000140124
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 67 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005102 receptor binding
GO:0005496 steroid binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001542 ovulation from ovarian follicle
GO:0002070 epithelial cell maturation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0010629 negative regulation of gene expression
GO:0030879 mammary gland development
GO:0043401 steroid hormone mediated signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050678 regulation of epithelial cell proliferation
GO:0050847 progesterone receptor signaling pathway
GO:0060748 tertiary branching involved in mammary gland duct morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Oocyte meiosis pathway
Progesterone-mediated oocyte maturation pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Signaling by ERBB4 pathway
Signal Transduction pathway
Nuclear Receptor transcription pathway pathway
Generic Transcription Pathway pathway
Nuclear signaling by ERBB4 pathway
Gene Expression pathway
KEGG
Oocyte meiosis pathway
Progesterone-mediated oocyte maturation pathway
INOH
PID BIOCARTA
How progesterone initiates the oocyte maturation [Biocarta view]
PID NCI
Validated nuclear estrogen receptor alpha network
Cellular roles of Anthrax toxin
Cross-References
SwissProt
TrEMBL A6H6A5 E9QPW3 Q8BW69
UniProt Splice Variant
Entrez Gene 18667
UniGene Mm.12798 Mm.405099
RefSeq NM_008829
OMIM
CCDS CCDS22816
HPRD
IMGT
MGI ID MGI:97567
MGI Symbol Pgr
EMBL AC113506 AC160964 AK054117 BC145807 CH466522
GenPept AAI45808 BAC35662 EDL24960
RNA Seq Atlas 18667