Homo sapiens Gene: BACH1
Summary
InnateDB Gene IDBG-1349.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BACH1
Gene Name BTB and CNC homology 1, basic leucine zipper transcription factor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000156273
Encoded Proteins
BTB and CNC homology 1, basic leucine zipper transcription factor 1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:29194071-29630751
Strand Forward strand
Band q21.3
Transcripts
ENST00000286800 ENSP00000286800
ENST00000399921 ENSP00000382805
ENST00000451655 ENSP00000400576
ENST00000447177 ENSP00000408605
ENST00000435072 ENSP00000392202
ENST00000422809 ENSP00000416569
ENST00000468059 ENSP00000470673
ENST00000462262
ENST00000548219 ENSP00000447332
ENST00000550131 ENSP00000449316
ENST00000547141 ENSP00000448663
ENST00000546469 ENSP00000449383
ENST00000548467 ENSP00000448982
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 50 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001206 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0020037 heme binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL C9IYH8 C9IYR0 C9JMP6 F8VZL7
UniProt Splice Variant
Entrez Gene 571
UniGene Hs.154276 Hs.602860
RefSeq NM_001186 NM_206866 XM_005261013 XM_005261012 XM_005261014
HUGO HGNC:935
OMIM 602751
CCDS CCDS13585
HPRD 04127
IMGT
EMBL AF124730 AF124731 AP000238 AP000239 AP000240
GenPept
RNA Seq Atlas 100379661 571