InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Creb3l2

Summary

InnateDB Gene

IDBG-136249.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Creb3l2

Gene Name

cAMP responsive element binding protein 3-like 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038648

Encoded Proteins

IDBP-136251

cAMP responsive element binding protein 3-like 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182158:
This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:37327255-37442146

Strand

Reverse strand

Band

Transcripts

ENSMUST00000041093	ENSMUSP00000040208
ENSMUST00000128534

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0035497	cAMP response element binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0002062	chondrocyte differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0006986	response to unfolded protein
GO:0034976	response to endoplasmic reticulum stress
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051216	cartilage development

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000182158

View Gene Order

ENSBTAG00000015802

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04916

Melanogenesis pathway

mmu05215

Prostate cancer pathway

mmu05016

Huntington's disease pathway

mmu04962

Vasopressin-regulated water reabsorption pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05215

Prostate cancer pathway

hsa04916

Melanogenesis pathway

hsa05016

Huntington's disease pathway

hsa04962

Vasopressin-regulated water reabsorption pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.169929 Mm.482172

RefSeq

NM_178661 XM_006544051

OMIM

CCDS

CCDS20006

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas