Homo sapiens Gene: TLR1
Summary
InnateDB Gene IDBG-13627.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLR1
Gene Name toll-like receptor 1
Synonyms CD281; rsc786; TIL; TIL. LPRS5;
Species Homo sapiens
Ensembl Gene ENSG00000174125
Encoded Proteins
toll-like receptor 1
toll-like receptor 1
toll-like receptor 1
toll-like receptor 1
toll-like receptor 1
toll-like receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TLR1 polymorphisms affect innate immune responses and outcomes in sepsis.
TLR1 restrains potentially dangerous innate response to LPS by binding to TLR4 and preventing the formation of active signalling complexes.
TLR1 interacts with TLR2 to recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.
TLR1 and TLR6 are involved in the discrimination of a subtle difference between triacyl and diacyl lipopeptides through interaction with TLR2.
TLR1 :: TLR2 dimeric pairs recognize malarial glycosylphosphatidylinositols (GPI) to initiates intracellular signalling and the production of pro-inflammatory cytokines.
TLR1 is a critical innate receptor for protective intestinal T(H)17 immunity against Yersinia enterocolitica. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Tlr1 :: Tlr2 dimeric pairs recognize malarial glycosylphosphatidylinositols (GPI) to initiates intracellular signalling and the production of pro-inflammatory cytokines.
[Mus musculus] Tlr1 is a critical innate receptor for protective intestinal T(H)17 immunity against Yersinia enterocolitica.
[Mus musculus] TLR1 in intestinal epithelium mediates activation and recruitment of dendritic cells to mount mucosal immunity against Yersinia enterocolitica.
Entrez Gene
Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:38790677-38856817
Strand Reverse strand
Band p14
Transcripts
ENST00000308979 ENSP00000354932
ENST00000510552
ENST00000505744
ENST00000502213 ENSP00000421259
ENST00000505940 ENSP00000421856
ENST00000515861 ENSP00000423017
ENST00000506146 ENSP00000423725
ENST00000508364 ENSP00000424894
ENST00000509754
ENST00000508535
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0034130 toll-like receptor 1 signaling pathway
GO:0042116 macrophage activation
GO:0042495 detection of triacyl bacterial lipopeptide
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045410 positive regulation of interleukin-6 biosynthetic process
GO:0050707 regulation of cytokine secretion
GO:0071727 cellular response to triacyl bacterial lipopeptide
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030670 phagocytic vesicle membrane
GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
Toll-like receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Endogenous TLR signaling
Cross-References
SwissProt Q15399
TrEMBL D6RA99 D6RAP2 D6RCE8 D6RF68
UniProt Splice Variant
Entrez Gene 7096
UniGene Hs.621817 Hs.654532
RefSeq NM_003263 XM_005262662 XM_005262663 XM_005262665 XM_005262666 XM_006714028
HUGO HGNC:11847
OMIM 601194
CCDS CCDS33973
HPRD
IMGT
EMBL AB445617 AC108044 AL050262 BC109093 BC109094 D13637 DQ012259 DQ012260 DQ012261 U88540
GenPept AAC34137 AAI09094 AAI09095 AAY85638 AAY85639 AAY85640 BAA02801 BAG55014 CAB43364
RNA Seq Atlas 7096