InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TLR6

Summary

InnateDB Gene

IDBG-13675.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TLR6

Gene Name

toll-like receptor 6

Synonyms

CD286

Species

Homo sapiens

Ensembl Gene

ENSG00000174130

Encoded Proteins

IDBP-13677

toll-like receptor 6

IDBP-365386

toll-like receptor 6

IDBP-479509

toll-like receptor 6

IDBP-475076

toll-like receptor 6

IDBP-809764

toll-like receptor 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 15661917

TLR6 co-expressed withTLR2 at the cell surface is crucial for recognition of diacylated lipopeptide and peptidoglycan derived from mycoplasma and to activate the NF-kappaB signalling cascades in human cells.

PMID 12697090

TLR6 and TLR1 are involved in the discrimination of a subtle difference between triacyl and diacyl lipopeptides through interaction with TLR2.

PMID 15690042

TLR6/2 heterodimer signalling is used by CD36, a selective and non-redundant sensor of microbial diacylglycerides.

PMID 20037584

TLR6-CD36-TLR4 activation is a common molecular mechanism by which atherogenic lipids and amyloid-beta stimulate sterile inflammation.

PMID 21482737

TLR2::TLR6 synergistically interacts with TLR9 in lung epithelium to induce rapid pathogen killing, and can be used as a therapeutic target to treat otherwise lethal pneumonia.

PMID 25456159

Cutaneous bacteria can negatively regulate skin-driven immune responses by inducing Gr1(+)CD11b(+) myeloid-derived suppressor cells via TLR2-6 activation.

Entrez Gene

Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:38823715-38856817

Strand

Reverse strand

Band

p14

Transcripts

ENST00000381950	ENSP00000371376
ENST00000436693	ENSP00000389600
ENST00000508254	ENSP00000424718
ENST00000514655	ENSP00000423326
ENST00000610323	ENSP00000480266

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0042498	diacyl lipopeptide binding
GO:0046982	protein heterodimerization activity
GO:0071723	lipopeptide binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034150	toll-like receptor 6 signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0042088	T-helper 1 type immune response
GO:0042496	detection of diacyl bacterial lipopeptide
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043507	positive regulation of JUN kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045410	positive regulation of interleukin-6 biosynthetic process
GO:0050707	regulation of cytokine secretion
GO:0071726	cellular response to diacyl bacterial lipopeptide

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030670	phagocytic vesicle membrane
GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex