InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aqp3

Summary

InnateDB Gene

IDBG-137002.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aqp3

Gene Name

aquaporin 3

Synonyms

AQP-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028435

Encoded Proteins

IDBP-137004

aquaporin 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21865318

Aqp3 is an aquaporin that functions in macrophage immunity by a cellular mechanism involving facilitated water and glycerol transport, and consequent phagocytic and migration activity. Aqp3, therefore, is a novel therapeutic target in modulating the innate immune response in various infectious and inflammatory conditions.

InnateDB Annotation from Orthologs

Summary

PMID 21865318

[Homo sapiens] AQP3 is an aquaporin that functions in macrophage immunity by a cellular mechanism involving facilitated water and glycerol transport, and consequent phagocytic and migration activity. AQP3, therefore, is a novel therapeutic target in modulating the innate immune response in various infectious and inflammatory conditions.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165272:
This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:41092722-41098183

Strand

Reverse strand

Band

Transcripts

ENSMUST00000055327	ENSMUSP00000055110
ENSMUST00000154722

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0015250	water channel activity
GO:0015254	glycerol channel activity

Biological Process

GO:0002684	positive regulation of immune system process
GO:0006810	transport
GO:0006833	water transport
GO:0015793	glycerol transport
GO:0015840	urea transport
GO:0032526	response to retinoic acid
GO:0042476	odontogenesis
GO:0045087	innate immune response (InnateDB)
GO:0070295	renal water absorption

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016323	basolateral plasma membrane