InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kcnma1

Summary

InnateDB Gene

IDBG-137748.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnma1

Gene Name

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

Synonyms

5730414M22Rik; BKCa; MaxiK; mSlo; mSlo1; Slo; Slo1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000063142

Encoded Proteins

IDBP-137750

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

IDBP-137752

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

IDBP-137754

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

IDBP-256033

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

IDBP-623926

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

IDBP-623927

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

IDBP-718540

IDBP-717490

IDBP-718636

IDBP-789003

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

IDBP-789004

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

IDBP-789005

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

IDBP-789006

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

IDBP-789007

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

IDBP-789008

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156113:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:23289431-24004859

Strand

Reverse strand

Band

Transcripts

ENSMUST00000074983	ENSMUSP00000074511
ENSMUST00000065788	ENSMUSP00000065293
ENSMUST00000100831	ENSMUSP00000098393
ENSMUST00000112423	ENSMUSP00000108042
ENSMUST00000163322	ENSMUSP00000128553
ENSMUST00000172099	ENSMUSP00000132204
ENSMUST00000177634	ENSMUSP00000136447
ENSMUST00000179836	ENSMUSP00000137141
ENSMUST00000179097	ENSMUSP00000136568
ENSMUST00000188285	ENSMUSP00000140275
ENSMUST00000188210	ENSMUSP00000141069
ENSMUST00000190985	ENSMUSP00000140154
ENSMUST00000190044	ENSMUSP00000140033
ENSMUST00000188991	ENSMUSP00000140751
ENSMUST00000190339	ENSMUSP00000141143

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005267	potassium channel activity
GO:0005515	protein binding
GO:0015269	calcium-activated potassium channel activity
GO:0060072	large conductance calcium-activated potassium channel activity

Biological Process

GO:0001666	response to hypoxia
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0006970	response to osmotic stress
GO:0007268	synaptic transmission
GO:0007605	sensory perception of sound
GO:0007623	circadian rhythm
GO:0007628	adult walking behavior
GO:0019228	neuronal action potential
GO:0030007	cellular potassium ion homeostasis
GO:0032344	regulation of aldosterone metabolic process
GO:0034465	response to carbon monoxide
GO:0042311	vasodilation
GO:0042391	regulation of membrane potential
GO:0042491	auditory receptor cell differentiation
GO:0043065	positive regulation of apoptotic process
GO:0045475	locomotor rhythm
GO:0045794	negative regulation of cell volume
GO:0046541	saliva secretion
GO:0048469	cell maturation
GO:0050885	neuromuscular process controlling balance
GO:0051260	protein homooligomerization
GO:0051592	response to calcium ion
GO:0055085	transmembrane transport
GO:0060073	micturition
GO:0060082	eye blink reflex
GO:0060083	smooth muscle contraction involved in micturition
GO:0060087	relaxation of vascular smooth muscle
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0008076	voltage-gated potassium channel complex
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0043195	terminal bouton
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome