Version 5.4
Homo sapiens Gene: CRBN
Summary
InnateDB Gene IDBG-13894.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRBN
Gene Name cereblon
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000113851
Encoded Proteins
IDBP-13898
cereblon
IDBP-360757
cereblon
IDBP-360761
cereblon
IDBP-360764
cereblon
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:3148992-3179710
Strand Reverse strand
Band p26.2
Transcripts
ENST00000231948 ENSP00000231948
ENST00000424814 ENSP00000411047
ENST00000432408 ENSP00000412499
ENST00000450014 ENSP00000392073
ENST00000491834
ENST00000488263
ENST00000459840
ENST00000498442
ENST00000482844
ENST00000480249
ENST00000498700
ENST00000492178
ENST00000478353
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004176 ATP-dependent peptidase activity
GO:0005515 protein binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006508 proteolysis
GO:0016567 protein ubiquitination
GO:0032463 negative regulation of protein homooligomerization
GO:0034766 negative regulation of ion transmembrane transport
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0090073 positive regulation of protein homodimerization activity
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005362
View Gene Order
ENSBTAG00000019536
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.18925 Hs.693173
RefSeq NM_001173482 NM_016302 XM_005265202
HUGO
OMIM
CCDS CCDS2562 CCDS54547
HPRD 16750
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca