Mus musculus Gene: Tdp2
Summary
InnateDB Gene IDBG-139097.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tdp2
Gene Name tyrosyl-DNA phosphodiesterase 2
Synonyms D13Ertd656e; Ttrap
Species Mus musculus
Ensembl Gene ENSMUSG00000035958
Encoded Proteins
tyrosyl-DNA phosphodiesterase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111802:
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:24831679-24842153
Strand Forward strand
Band A3.1
Transcripts
ENSMUST00000038039 ENSMUSP00000035660
ENSMUST00000130788
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003697 single-stranded DNA binding
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
GO:0030145 manganese ion binding
GO:0036317 tyrosyl-RNA phosphodiesterase activity
GO:0070260 5'-tyrosyl-DNA phosphodiesterase activity
Biological Process
GO:0006302 double-strand break repair
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016605 PML body
GO:0045171 intercellular bridge
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
CD40/CD40L signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.473059
RefSeq NM_019551
OMIM
CCDS CCDS26381
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas