Version 5.4
Mus musculus Gene: Defb15
Summary
InnateDB Gene IDBG-139364.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Defb15
Gene Name defensin beta 15
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000048500
Encoded Proteins
IDBP-139366
defensin beta 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187082:
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106B, represents the more telomeric copy. [provided by RefSeq, Jul 2008] Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106A, represents the more centromeric copy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:21929799-21932710
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000062586 ENSMUSP00000059763
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
GO:0042742 defense response to bacterium
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
ENSG00000187082
View Gene Order
RBBH
Low
Tentative data, uncurated. RBBH derived.
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_115846
Defensins pathway
REACT_6802
Innate Immune System pathway
REACT_115897
Beta defensins pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8R2I5
TrEMBL
UniProt Splice Variant
Entrez Gene 246082
UniGene Mm.390015
RefSeq NM_139222
OMIM
CCDS CCDS40288
HPRD
IMGT
MGI ID MGI:2179202
MGI Symbol Defb15
EMBL AJ437648 AJ575428 AL590619
GenPept CAD26897 CAE01401 CAM22058
RNA Seq Atlas 246082

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca