InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LTBR

Summary

InnateDB Gene

IDBG-13973.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LTBR

Gene Name

lymphotoxin beta receptor (TNFR superfamily, member 3)

Synonyms

CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR; TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3

Species

Homo sapiens

Ensembl Gene

ENSG00000111321

Encoded Proteins

IDBP-13975

lymphotoxin beta receptor (TNFR superfamily, member 3)

IDBP-587856

lymphotoxin beta receptor (TNFR superfamily, member 3)

IDBP-601619

lymphotoxin beta receptor (TNFR superfamily, member 3)

IDBP-585208

lymphotoxin beta receptor (TNFR superfamily, member 3)

IDBP-584086

lymphotoxin beta receptor (TNFR superfamily, member 3)

IDBP-587490

lymphotoxin beta receptor (TNFR superfamily, member 3)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20226692

LTBR signalling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection.

PMID 21767811

LTBR signalling in the gut lymphoid follicles regulates IL22 production by innate lymphoid cells in response to mucosal pathogen challenge. (Demonstrated in mouse)

InnateDB Annotation from Orthologs

Summary

PMID 21767811

[Mus musculus] Ltbr signalling in the gut lymphoid follicles regulates Il22 production by innate lymphoid cells in response to mucosal pathogen challenge.

Entrez Gene

Summary

This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:6375045-6391571

Strand

Forward strand

Band

p13.31

Transcripts

ENST00000228918	ENSP00000228918
ENST00000444814
ENST00000441074
ENST00000440421
ENST00000546296
ENST00000542830
ENST00000539925	ENSP00000440875
ENST00000536876	ENSP00000437647
ENST00000535739
ENST00000543190	ENSP00000438955
ENST00000545445
ENST00000544454	ENSP00000437954
ENST00000541102	ENSP00000438605
ENST00000541005
ENST00000543542

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0016032	viral process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0046330	positive regulation of JNK cascade
GO:0071260	cellular response to mechanical stimulus
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0016021

integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030339

View Gene Order

ENSBTAG00000015312

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04672

Intestinal immune network for IgA production pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.1116

RefSeq

NM_001270987 NM_002342

HUGO

OMIM

CCDS

CCDS59233 CCDS8544

HPRD

02988

IMGT

EMBL

GenPept

RNA Seq Atlas