Homo sapiens Gene: CPT1B
Summary
InnateDB Gene IDBG-14004.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPT1B
Gene Name carnitine palmitoyltransferase 1B (muscle)
Synonyms CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1; MCCPT1; MCPT1;
Species Homo sapiens
Ensembl Gene ENSG00000205560
Encoded Proteins
carnitine palmitoyltransferase 1B (muscle)
carnitine palmitoyltransferase 1B (muscle)
carnitine palmitoyltransferase 1B (muscle)
carnitine palmitoyltransferase 1B (muscle)
carnitine palmitoyltransferase 1B (muscle)
carnitine palmitoyltransferase 1B (muscle)
carnitine palmitoyltransferase 1B (muscle)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. [provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:50568861-50578465
Strand Reverse strand
Band q13.33
Transcripts
ENST00000360719 ENSP00000353945
ENST00000312108 ENSP00000312189
ENST00000395650 ENSP00000379011
ENST00000405237 ENSP00000385486
ENST00000457250 ENSP00000409342
ENST00000423069 ENSP00000396408
ENST00000417176 ENSP00000406316
ENST00000497224
ENST00000475238
ENST00000479886
ENST00000476790
ENST00000460853
ENST00000461117
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004095 carnitine O-palmitoyltransferase activity
GO:0005515 protein binding
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0006853 carnitine shuttle
GO:0008152 metabolic process
GO:0015909 long-chain fatty acid transport
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Import of palmitoyl-CoA into the mitochondrial matrix pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
KEGG
Fatty acid degradation pathway
PPAR signaling pathway pathway
Adipocytokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.609867
RefSeq NM_001145134 NM_001145135 NM_001145136 NM_001145137 NM_004377 NM_152245 NM_152246
HUGO
OMIM
CCDS CCDS14098 CCDS46734
HPRD 09065
IMGT
EMBL
GenPept
RNA Seq Atlas