InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CPT1B

Summary

InnateDB Gene

IDBG-14004.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CPT1B

Gene Name

carnitine palmitoyltransferase 1B (muscle)

Synonyms

CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1; MCCPT1; MCPT1

Species

Homo sapiens

Ensembl Gene

ENSG00000205560

Encoded Proteins

IDBP-13909

carnitine palmitoyltransferase 1B (muscle)

IDBP-14006

carnitine palmitoyltransferase 1B (muscle)

IDBP-239085

carnitine palmitoyltransferase 1B (muscle)

IDBP-295522

carnitine palmitoyltransferase 1B (muscle)

IDBP-381517

carnitine palmitoyltransferase 1B (muscle)

IDBP-381523

carnitine palmitoyltransferase 1B (muscle)

IDBP-381526

carnitine palmitoyltransferase 1B (muscle)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:50568861-50578465

Strand

Reverse strand

Band

q13.33

Transcripts

ENST00000360719	ENSP00000353945
ENST00000312108	ENSP00000312189
ENST00000395650	ENSP00000379011
ENST00000405237	ENSP00000385486
ENST00000457250	ENSP00000409342
ENST00000423069	ENSP00000396408
ENST00000417176	ENSP00000406316
ENST00000497224
ENST00000475238
ENST00000479886
ENST00000476790
ENST00000460853
ENST00000461117

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004095	carnitine O-palmitoyltransferase activity
GO:0005515	protein binding
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0006635	fatty acid beta-oxidation
GO:0006853	carnitine shuttle
GO:0008152	metabolic process
GO:0015909	long-chain fatty acid transport
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000078937

View Gene Order

ENSBTAG00000016048

Not yet available

Pathways

NETPATH

REACTOME

REACT_11082

Import of palmitoyl-CoA into the mitochondrial matrix pathway

REACT_22279

Fatty acid, triacylglycerol, and ketone body metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa00071

Fatty acid degradation pathway

hsa03320

PPAR signaling pathway pathway

hsa04920

Adipocytokine signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

Q92523

TrEMBL

A0A024R4W7 C9J7C3 K7N7A7

UniProt Splice Variant

Entrez Gene

1375

UniGene

Hs.609867

RefSeq

NM_001145135 NM_001145136 NM_001145137 NM_152245 NM_001145134 NM_004377 NM_152246

HUGO

HGNC:2329

OMIM

601987

CCDS

CCDS14098 CCDS46734

HPRD

09065

IMGT

EMBL

AB003286 AB051457 AK297866 AK299395 CH471138 D87812 U62317 U62733 U66828 Y08682 Y08683

GenPept

AAB03343 AAB40651 AAC51122 BAA13461 BAA21492 BAB33340 BAH12680 BAH13024 CAA69938 CAA69939 EAW73568 EAW73569 EAW73570 EAW73571 EAW73572

RNA Seq Atlas

1375