Version 5.4
Mus musculus Gene: Pes1
Summary
InnateDB Gene IDBG-141300.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pes1
Gene Name pescadillo homolog 1, containing BRCT domain (zebrafish)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020430
Encoded Proteins
IDBP-141302
pescadillo homolog 1, containing BRCT domain (zebrafish)
IDBP-261232
pescadillo homolog 1, containing BRCT domain (zebrafish)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100029:
This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:3963975-3980004
Strand Forward strand
Band A1
Transcripts
ENSMUST00000020705 ENSMUSP00000020705
ENSMUST00000109985 ENSMUSP00000105612
ENSMUST00000130973
ENSMUST00000137544
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0007000 nucleolus organization
GO:0008283 cell proliferation
GO:0033365 protein localization to organelle
GO:0042254 ribosome biogenesis
GO:0051726 regulation of cell cycle
Cellular Component
GO:0000793 condensed chromosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030687 preribosome, large subunit precursor
GO:0070545 PeBoW complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100029
View Gene Order
ENSBTAG00000007728
Not yet available
Cross-References
SwissProt
TrEMBL Q5SQ20
UniProt Splice Variant
Entrez Gene 64934
UniGene Mm.28659 Mm.390084
RefSeq NM_022889
OMIM
CCDS CCDS24372
HPRD
IMGT
MGI ID MGI:1890613
MGI Symbol Pes1
EMBL AL807395
GenPept
RNA Seq Atlas 64934

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca