InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Casp2

Summary

InnateDB Gene

IDBG-141522.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casp2

Gene Name

caspase 2

Synonyms

Caspase-2; ICH-1; Nedd2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029863

Encoded Proteins

IDBP-141524

caspase 2

IDBP-536482

caspase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26341399

Nlrp3 and Casp2 are required for endoplasmic reticulum stress-induced inflammation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106144:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer\'s disease, Huntington\'s disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:42264985-42282508

Strand

Forward strand

Band

B2.1

Transcripts

ENSMUST00000031895	ENSMUSP00000031895
ENSMUST00000139930
ENSMUST00000156829	ENSMUSP00000121184
ENSMUST00000132246
ENSMUST00000141669
ENSMUST00000144821
ENSMUST00000132398
ENSMUST00000152893
ENSMUST00000141727

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0019904	protein domain specific binding
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process

Biological Process

GO:0001554	luteolysis
GO:0003407	neural retina development
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007420	brain development
GO:0007568	aging
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016485	protein processing
GO:0035234	ectopic germ cell programmed cell death
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0071260	cellular response to mechanical stimulus
GO:0097190	apoptotic signaling pathway
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2001235	positive regulation of apoptotic signaling pathway