Version 5.4
Mus musculus Gene: Arvcf
Summary
InnateDB Gene IDBG-141624.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arvcf
Gene Name armadillo repeat gene deleted in velo-cardio-facial syndrome
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000000325
Encoded Proteins
IDBP-141626
armadillo repeat gene deleted in velo-cardio-facial syndrome
IDBP-249231
armadillo repeat gene deleted in velo-cardio-facial syndrome
IDBP-249233
armadillo repeat gene deleted in velo-cardio-facial syndrome
IDBP-249235
armadillo repeat gene deleted in velo-cardio-facial syndrome
IDBP-249239
armadillo repeat gene deleted in velo-cardio-facial syndrome
IDBP-537455
armadillo repeat gene deleted in velo-cardio-facial syndrome
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099889:
Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. This family plays an important role in the formation of adherens junction complexes, which are thought to facilitate communication between the inside and outside environments of a cell. The ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. The ARVCF gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion. Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:18348182-18407076
Strand Forward strand
Band A3
Transcripts
ENSMUST00000090103 ENSMUSP00000087562
ENSMUST00000115614 ENSMUSP00000111278
ENSMUST00000115613 ENSMUSP00000111276
ENSMUST00000115612 ENSMUSP00000111275
ENSMUST00000115610 ENSMUSP00000111273
ENSMUST00000150253 ENSMUSP00000118505
ENSMUST00000155548
ENSMUST00000126183
ENSMUST00000150484
ENSMUST00000152132
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0016337 single organismal cell-cell adhesion
GO:0016339 calcium-dependent cell-cell adhesion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000099889
View Gene Order
ENSBTAG00000001473
Not yet available
Cross-References
SwissProt
TrEMBL D6RI19
UniProt Splice Variant
Entrez Gene 11877
UniGene Mm.293599 Mm.403331
RefSeq NM_001272028 NM_001272029 NM_001272030 NM_001272031 NM_001272032 NM_033474 XM_006521719 XM_006536859 XM_006536860 XM_006544939
OMIM
CCDS CCDS28020 CCDS70693 CCDS70694
HPRD
IMGT
MGI ID MGI:109620
MGI Symbol Arvcf
EMBL AC084822 AC133487
GenPept
RNA Seq Atlas 11877

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca