Version 5.4
Mus musculus Gene: Pax5
Summary
InnateDB Gene IDBG-143469.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pax5
Gene Name paired box gene 5
Synonyms BSAP; EBB-1; KLP; Pax-5
Species Mus musculus
Ensembl Gene ENSMUSG00000014030
Encoded Proteins
IDBP-143471
paired box gene 5
IDBP-143473
paired box gene 5
IDBP-265842
paired box gene 5
IDBP-265844
paired box gene 5
IDBP-265846
paired box gene 5
IDBP-623829
paired box gene 5
IDBP-789390
paired box 5
IDBP-623835
paired box gene 5
IDBP-623837
paired box gene 5
IDBP-623839
paired box gene 5
IDBP-623841
paired box gene 5
IDBP-623842
paired box gene 5
IDBP-623845
paired box gene 5
IDBP-623849
paired box gene 5
IDBP-789391
paired box 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196092:
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:44531145-44710487
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000102932 ENSMUSP00000099996
ENSMUST00000014174 ENSMUSP00000014174
ENSMUST00000107827 ENSMUSP00000103458
ENSMUST00000107826 ENSMUSP00000103457
ENSMUST00000107825 ENSMUSP00000103455
ENSMUST00000143235 ENSMUSP00000134370
ENSMUST00000146335 ENSMUSP00000139296
ENSMUST00000134968 ENSMUSP00000133540
ENSMUST00000173821 ENSMUSP00000134712
ENSMUST00000174319 ENSMUSP00000133978
ENSMUST00000173733 ENSMUSP00000133671
ENSMUST00000172866 ENSMUSP00000134119
ENSMUST00000174242 ENSMUSP00000134391
ENSMUST00000165417 ENSMUSP00000128880
ENSMUST00000172949
ENSMUST00000174761
ENSMUST00000187197
ENSMUST00000186542 ENSMUSP00000141186
ENSMUST00000191036
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 14 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007283 spermatogenesis
GO:0007399 nervous system development
GO:0009887 organ morphogenesis
GO:0035914 skeletal muscle cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051573 negative regulation of histone H3-K9 methylation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000196092
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_5
ID pathway
REACTOME
KEGG
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.439659
RefSeq NM_008782 XM_006537673 XM_006537674
OMIM
CCDS CCDS18125
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca