Version 5.4
Mus musculus Gene: Paxip1
Summary
InnateDB Gene IDBG-143920.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Paxip1
Gene Name PAX interacting (with transcription-activation domain) protein 1
Synonyms D5Ertd149e; PTIP
Species Mus musculus
Ensembl Gene ENSMUSG00000002221
Encoded Proteins
IDBP-143922
PAX interacting (with transcription-activation domain) protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear-localized protein that contains six BRCT1 (C-terminal of breast cancer susceptibility protein) domains. The encoded protein is involved in the repair of DNA double-strand breaks and is necessary for progression through cell division. The protein also functions in the regulation of transcription by recruiting histone methyltransferases to gene promoters bound by the sequence-specific transcription factor paired box protein 2 (Pax2). [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:27740667-27791339
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000002291 ENSMUSP00000002291
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 240 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 240 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000416 positive regulation of histone H3-K36 methylation
GO:0001570 vasculogenesis
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006351 transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0010212 response to ionizing radiation
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0031398 positive regulation of protein ubiquitination
GO:0035066 positive regulation of histone acetylation
GO:0043542 endothelial cell migration
GO:0045830 positive regulation of isotype switching
GO:0051568 histone H3-K4 methylation
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060612 adipose tissue development
GO:0060717 chorion development
Cellular Component
GO:0005634 nucleus
GO:0016363 nuclear matrix
GO:0035097 histone methyltransferase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000157212
View Gene Order
ENSBTAG00000017505
Not yet available
Cross-References
SwissProt Q6NZQ4
TrEMBL
UniProt Splice Variant
Entrez Gene 55982
UniGene Mm.277190
RefSeq NM_018878
OMIM
CCDS CCDS39039
HPRD
IMGT
MGI ID MGI:1890430
MGI Symbol Paxip1
EMBL AF104261 AK144606 BC066014
GenPept AAD17923 AAH66014 BAE25965
RNA Seq Atlas 55982

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca