Version 5.4
Homo sapiens Gene: DAZAP1
Summary
InnateDB Gene IDBG-14425.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAZAP1
Gene Name DAZ associated protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000071626
Encoded Proteins
IDBP-14427
DAZ associated protein 1
IDBP-14429
DAZ associated protein 1
IDBP-760936
IDBP-765420
IDBP-765937
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:1407569-1435687
Strand Forward strand
Band p13.3
Transcripts
ENST00000336761 ENSP00000337132
ENST00000233078 ENSP00000233078
ENST00000589484
ENST00000587833
ENST00000585485
ENST00000586579
ENST00000592453 ENSP00000467613
ENST00000592522 ENSP00000467680
ENST00000589874
ENST00000590419
ENST00000587079 ENSP00000465433
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0035613 RNA stem-loop binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001893 maternal placenta development
GO:0007283 spermatogenesis
GO:0008283 cell proliferation
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000069565
View Gene Order
ENSBTAG00000019714
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q5IRM7
UniProt Splice Variant
Entrez Gene 26528
UniGene Hs.222510 Hs.713659 Hs.740217
RefSeq NM_018959 NM_170711 XM_005259530 XM_005259531 XM_005259532
HUGO HGNC:2683
OMIM 607430
CCDS CCDS12065 CCDS12066
HPRD 08462
IMGT
EMBL AY681494
GenPept AAW01463
RNA Seq Atlas 26528

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca