Version 5.4
Mus musculus Gene: Lsm1
Summary
InnateDB Gene IDBG-144458.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lsm1
Gene Name LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Synonyms 2810025O06Rik; CASM
Species Mus musculus
Ensembl Gene ENSMUSG00000037296
Encoded Proteins
IDBP-144460
LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175324:
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:25785591-25803975
Strand Forward strand
Band A2
Transcripts
ENSMUST00000038421 ENSMUSP00000041022
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0071044 histone mRNA catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000175324
View Gene Order
ENSBTAG00000001612
Not yet available
Pathways
NETPATH
REACTOME
REACT_261877
mRNA decay by 5' to 3' exoribonuclease pathway
REACT_233572
Gene Expression pathway
REACT_235784
Deadenylation-dependent mRNA decay pathway
KEGG
mmu03018
RNA degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20518
mRNA decay by 5' to 3' exoribonuclease pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
REACT_207715
mRNA decay by 5' to 3' exoribonuclease pathway
REACT_226022
Gene Expression pathway
REACT_203426
Deadenylation-dependent mRNA decay pathway
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt Q8VC85
TrEMBL Q544C9 Q9CR79 Q9CRP6
UniProt Splice Variant
Entrez Gene 67207
UniGene
RefSeq NM_026032
OMIM
CCDS CCDS22202
HPRD
IMGT
MGI ID MGI:1914457
MGI Symbol Lsm1
EMBL AK006006 AK012814 AK019398 AK041290 BC021460 CH466580
GenPept AAH21460 BAB24361 BAB28489 BAB31701 BAC30891 EDL32821
RNA Seq Atlas 67207

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca