Mus musculus Gene: Amd1
Summary
InnateDB Gene IDBG-145376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Amd1
Gene Name S-adenosylmethionine decarboxylase 1
Synonyms 1; AdoMetDC; adoMetDC1; Amd-1; SAMDC; SAMDC 1;
Species Mus musculus
Ensembl Gene ENSMUSG00000075232
Encoded Proteins
S-adenosylmethionine decarboxylase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123505:
This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Two alternatively spliced transcript variants that encode different proteins have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y.[provided by RefSeq, Jul 2010]
This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:40287458-40302188
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000099945 ENSMUSP00000097528
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004014 adenosylmethionine decarboxylase activity
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006557 S-adenosylmethioninamine biosynthetic process
GO:0006597 spermine biosynthetic process
GO:0008295 spermidine biosynthetic process
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Metabolism of polyamines pathway
KEGG
Cysteine and methionine metabolism pathway
Arginine and proline metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of polyamines pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
Metabolism of polyamines pathway
KEGG
Cysteine and methionine metabolism pathway
Arginine and proline metabolism pathway
INOH
Arginine Proline metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P31154 P82184
TrEMBL Q3TJI4
UniProt Splice Variant
Entrez Gene 11702
UniGene Mm.417327 Mm.420894 Mm.431851
RefSeq NM_009665
OMIM
CCDS CCDS48544
HPRD
IMGT
MGI ID MGI:88004
MGI Symbol Amd1
EMBL AB025024 AK146840 AK166187 AK167423 AK168165 BC011110 BC071220 BC080791 BC092072 BC138696 BC138697 CH466528 CH466540 CT010192 D12780 Z14986 Z23077
GenPept AAH11110 AAH71220 AAH80791 AAH92072 AAI38697 AAI38698 BAA02243 BAA83784 BAE27473 BAE38617 BAE39511 BAE40126 CAA78710 CAA80614 CAJ18400 EDL04951 EDL09708
RNA Seq Atlas 11702