Mus musculus Gene: Prpf19
Summary
InnateDB Gene IDBG-145419.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prpf19
Gene Name PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
Synonyms AA617263; AL024362; D19Wsu55e; NMP200; Prp19; PSO4; Snev;
Species Mus musculus
Ensembl Gene ENSMUSG00000024735
Encoded Proteins
PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110107:
PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).[supplied by OMIM, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:10895231-10909559
Strand Forward strand
Band A
Transcripts
ENSMUST00000025642 ENSMUSP00000025642
ENSMUST00000179297 ENSMUSP00000136858
ENSMUST00000178868
ENSMUST00000186416
ENSMUST00000187751
ENSMUST00000190275
ENSMUST00000191092
ENSMUST00000191552
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 81 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 81 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0034450 ubiquitin-ubiquitin ligase activity
GO:0042802 identical protein binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0000245 spliceosomal complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0001833 inner cell mass cell proliferation
GO:0006281 DNA repair
GO:0008610 lipid biosynthetic process
GO:0016567 protein ubiquitination
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0048026 positive regulation of mRNA splicing, via spliceosome
GO:0048711 positive regulation of astrocyte differentiation
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0005811 lipid particle
GO:0005819 spindle
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
Spliceosome pathway
Ubiquitin mediated proteolysis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
mRNA Splicing - Major Pathway pathway
mRNA Splicing pathway
Gene Expression pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
Spliceosome pathway
Ubiquitin mediated proteolysis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001253843 NM_001253844 NM_134129
OMIM
CCDS CCDS57135
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas