InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prpf19

Summary

InnateDB Gene

IDBG-145419.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prpf19

Gene Name

PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)

Synonyms

AA617263; AL024362; D19Wsu55e; NMP200; Prp19; PSO4; Snev

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024735

Encoded Proteins

IDBP-145421

PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)

IDBP-705122

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110107:
PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).[supplied by OMIM, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:10895231-10909559

Strand

Forward strand

Band

Transcripts

ENSMUST00000025642	ENSMUSP00000025642
ENSMUST00000179297	ENSMUSP00000136858
ENSMUST00000178868
ENSMUST00000186416
ENSMUST00000187751
ENSMUST00000190275
ENSMUST00000191092
ENSMUST00000191552

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 81 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	81 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0034450	ubiquitin-ubiquitin ligase activity
GO:0042802	identical protein binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0000245	spliceosomal complex assembly
GO:0000398	mRNA splicing, via spliceosome
GO:0001833	inner cell mass cell proliferation
GO:0006281	DNA repair
GO:0008610	lipid biosynthetic process
GO:0016567	protein ubiquitination
GO:0045665	negative regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0048026	positive regulation of mRNA splicing, via spliceosome
GO:0048711	positive regulation of astrocyte differentiation

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0000974	Prp19 complex
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0005811	lipid particle
GO:0005819	spindle
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0071013	catalytic step 2 spliceosome