Version 5.4
Mus musculus Gene: Traf2
Summary
InnateDB Gene IDBG-146254.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Traf2
Gene Name TNF receptor-associated factor 2
Synonyms AI325259
Species Mus musculus
Ensembl Gene ENSMUSG00000026942
Encoded Proteins
IDBP-146256
TNF receptor-associated factor 2
IDBP-252188
TNF receptor-associated factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22546736
Traf2 deficiency results in the accumulation of Tnf-dependent, Il10-secreting neutrophils. Combined treatment of neutralizing antibodies against both Tnf and Il10 substantially ameliorated the colitis phenotype in the Traf2 null mice.
PMID 23951545
The binding of MAVS to Traf2, Traf5, and Traf6 is dependent on virus infection and MAVS polymerization . The TRAF proteins promote ubiquitination that recruits IKBKG binding to the MAVS signalling complex.
PMID 25565375
Traf2 mediates proteasome-dependent degradation of Irf5 and Rel as well as regulating macrophage polarization in tumour microenvironment and controlling tumour growth.
PMID 25752829
Traf2-deficient macrophages produce reduced levels of inflammatory cytokines in response to lipopolysaccharide or flagellin stimulation and exhibit increased susceptibility to S. Typhimurium infection.
InnateDB Annotation from Orthologs
Summary
PMID 11479302
[Homo sapiens] TRAF2 and TRAF5 are signal transducers for the TNF receptor superfamily and are involved in TNF-induced NF-kappaB activation and protection from cell death.
PMID 19150425
[Homo sapiens] TRAF2 plays a critical role in TNF signalling by directing the IKK complex to the membrane, promoting TRAF2 K63-linked ubiquitination, and positioning the IKKalpha and IKKbeta chains with the TAK1/TAB kinase.
PMID 20449947
[Homo sapiens] TRAF2 competes with TRAF6 for CD40 binding, thereby limiting the capacity of CD40 engagement to induce NF-kappaB activation in human lymphocytes.
PMID 22546736
[Homo sapiens] TRAF2 deficiency results in the accumulation of TNF-dependent, IL10-secreting neutrophils. Combined treatment of neutralizing antibodies against both TNF and IL10 substantially ameliorated the colitis phenotype in the Traf2 null mice. (Demonstrated in mice)
PMID 24323043
[Homo sapiens] GNB2L1 (RACK1) negatively regulates NFκB activation by interacting with CHUK and IKBKB. The interaction interferes with the recruitment of the IKK complex to TRAF2 .
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127191:
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:25517982-25546940
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000028311 ENSMUSP00000028311
ENSMUST00000114234 ENSMUSP00000109872
ENSMUST00000151742
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 112 experimentally validated interaction(s) in this database.
They are also associated with 249 interaction(s) predicted by orthology.
Experimentally validated
Total 112 [view]
Protein-Protein 111 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 249 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005102 receptor binding
GO:0005164 tumor necrosis factor receptor binding
GO:0005174 CD40 receptor binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031996 thioesterase binding
GO:0032403 protein complex binding
GO:0042802 identical protein binding
GO:0046625 sphingolipid binding
Biological Process
GO:0002726 positive regulation of T cell cytokine production
GO:0006461 protein complex assembly
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0030163 protein catabolic process
GO:0032743 positive regulation of interleukin-2 production
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034351 negative regulation of glial cell apoptotic process
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043507 positive regulation of JUN kinase activity
GO:0043623 cellular protein complex assembly
GO:0045087 innate immune response (InnateDB)
GO:0046328 regulation of JNK cascade
GO:0051023 regulation of immunoglobulin secretion
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051291 protein heterooligomerization
GO:0051865 protein autoubiquitination
GO:0070207 protein homotrimerization
GO:0070534 protein K63-linked ubiquitination
GO:0071732 cellular response to nitric oxide
GO:0090073 positive regulation of protein homodimerization activity
GO:0097300 programmed necrotic cell death
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005938 cell cortex
GO:0009898 cytoplasmic side of plasma membrane
GO:0035631 CD40 receptor complex
GO:0043234 protein complex
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000127191
View Gene Order
ENSBTAG00000010497
Not yet available
Pathways
NETPATH
REACTOME
REACT_202898
TRAF6 mediated NF-kB activation pathway
REACT_239142
Innate Immune System pathway
REACT_258521
Apoptosis pathway
REACT_243608
Dimerization of procaspase-8 pathway
REACT_230745
Immune System pathway
REACT_256171
TNF signaling pathway
REACT_198521
TRAF6 mediated IRF7 activation pathway
REACT_241657
Caspase-8 activation by cleavage pathway
REACT_257735
Death Receptor Signalling pathway
REACT_215122
Regulation by c-FLIP pathway
REACT_259850
Extrinsic Pathway for Apoptosis pathway
REACT_219118
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
KEGG
mmu04010
MAPK signaling pathway pathway
mmu05222
Small cell lung cancer pathway
mmu04920
Adipocytokine signaling pathway pathway
mmu04210
Apoptosis pathway
mmu05200
Pathways in cancer pathway
mmu04622
RIG-I-like receptor signaling pathway pathway
mmu04380
Osteoclast differentiation pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
mmu05160
Hepatitis C pathway
INOH
INOH website
TNFR1 signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
NetPath_21
RANKL pathway
NetPath_26
TWEAK pathway
REACTOME
REACT_24938
TRAF6 mediated IRF7 activation pathway
REACT_24969
TRAF6 mediated NF-kB activation pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_832
Dimerization of procaspase-8 pathway
REACT_1503
Caspase-8 activation by cleavage pathway
REACT_1432
TNF signaling pathway
REACT_1059
Extrinsic Pathway for Apoptosis pathway
REACT_6802
Innate Immune System pathway
REACT_578
Apoptosis pathway
REACT_6900
Immune System pathway
REACT_164011
Regulation by c-FLIP pathway
REACT_1619
Death Receptor Signalling pathway
KEGG
hsa04210
Apoptosis pathway
hsa04010
MAPK signaling pathway pathway
hsa05222
Small cell lung cancer pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
hsa04380
Osteoclast differentiation pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
TNFR1 signaling pathway pathway
PID NCI
cd40_pathway
CD40/CD40L signaling
ceramide_pathway
Ceramide signaling pathway
caspase_pathway
Caspase Cascade in Apoptosis
tnfpathway
TNF receptor signaling pathway
trail_pathway
TRAIL signaling pathway
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
p38_mkk3_6pathway
p38 MAPK signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3399
RefSeq NM_001290413 NM_009422 XM_006497847 XM_006497848
OMIM
CCDS CCDS15779 CCDS71002
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca